Whats the difference between MDMA and Anti-Depressants

 PsYcheDeLiC (@xavv) 7 years, 9 months ago

Obviously we can firstly say their chemical composition is of a different nature.

How does each act inside the brain.

They both essentially make you extremely happy.

I think anti-depressants on a daily basis are personally detrimental to ones own cognitive health.

MDMA is something you use probably once every two or three months just for fun.

I would probably classify each as damaging as the other. But I want your guys clarification on it before I can sufficiently confirm it. I was thinking about it last night, and thought i’d love to ask you guys.

Please share your take and draw a contrast so as to clear this up :) thnx guys!

December 24, 2013 at 1:28 pm
Ellie (1,363)M (@tangledupinplaid21) 7 years, 9 months ago ago

@xavv, I can’t speak for the difference in chemical structure or anything of that nature on these things, but I’d say the difference is one is intended to be an experience of a few hours, and the other is meant to be administered over time and not necessarily have immediate effects.

inna (95) (@paintedbeings) 7 years, 9 months ago ago

I don’t think there could be a fit-for-all-cases depression drug since everyone’s cause and story is different and their happiness is found in a unique personal place. People often have other mental issues hand in hand with depression and have a variety of patterns of behavior that need to be considered along with the drug effects.

inna (95) (@paintedbeings) 7 years, 9 months ago ago

also, how do you feel about mushrooms in this context?

John “Avy” (57) (@Avernus) 7 years, 9 months ago ago

Have you tried either? Their effects are drastically different and they work on different receptors.

Antidepressents come in a variety of forms. Tricyclic, SSRIs, MAOIs, SNRIs.
most anti depressents are SSRIs or Selective Serotonin Reuptake Inhibitors – they let more serotonin build up in your synapses to make you “happier” but thats not the case with a lot of people, myself included. I’ve been on a few SSRIs and they never even made me feel happier, just less down. My world became grey. I wasn’t depressed so to say but I wasn’t happy or anything else, just meh. I can’t say its good to take these on a daily basis, not to mention the other side effects I had were unpleasant. But they seem to work for some people.

MDMA on the other hand causes you to release a large amount of serotonin and dopamine/norepinephrine to a smaller extent. It also increases oxytocin levels which account for the bonding that may occur and in part the entactogenic effects. lots of therapeutic potential here if used right.

VERY different drugses, SSRIs will drastically lessen or cancel out the effects of MDA/MDMA. MDMA actually makes me feel happy, nothing like the SSRIs I’ve taken.

JonH (1,139)C (@IJesusChrist) 7 years, 9 months ago ago

What John said was really well put. The antidepressants that generally come from pharmaceuticals STOP the break down of things in the brain. That is their major function. They keep the tryptamines and phenethylamines (Serotonin and dopamine) at elevated levels in the brain.

In general, most anti-depressants are ANTAGONISTS. This means they stop enzymes from working. Some of these have very round-about ways of doing it, like SSRIs, and others have very, very global effects (over the whole body they change things, MAOi’s).

MDMA however, is a (weak) AGONIST to the serotonin receptors AS WELL as being an inhibitor of re-uptake of amines (just like SSRI’s). This agonistic effect on the serotonin levels is hypothesized to be the reason oxytocin is released, which is that incredible warm-lovey-dovey feeling people get.

Pharmaceutical anti-depressants remove this effect – they don’t want to elevate your mood because this is not a sustainable (daily) routine. The SSRI’s themselves also are /selective/ on serotonin re-uptake – they only inhibit SOME serotonin re-uptake. The pathways in which they effect are basically just gambled upon to make you feel better. They don’t have a fucking clue, really. They just keep trying new SSRI’s thinking that one of them is bound to work.

Brendan Barstow (182)C (@eyesopen) 7 years, 9 months ago ago

John nailed it with a combination of science and anecdote! I will add, however, that MDMA and SSRIs DO NOT CANCEL EACH OTHER OUT! They work synergistically upon the serotonergic system, greatly increasing the risk of serotonin syndrome. You don’t want serotonin syndrome.

John “Avy” (57) (@Avernus) 7 years, 9 months ago ago

I thought that was primarily MAOIs… but it makes sense with SSRIs too. either way, don’t do!

John “Avy” (57) (@Avernus) 7 years, 9 months ago ago

Did a little reading on multiple sources and figured I should share, looks like you won’t have to worry about Serotonin Syndrome with SSRIs and MDMA. It was well put on shroomery from a guy with his PHD in pharmacology

“That being said, here’s my analysis of the interaction between SSRI’s & MDMA: While it seems to make theoretical sense that concurrent use of SSRI’s & MDMA could cause serotonin syndrome by stimulating the release of 5HT (serotonin) while also blocking it’s reuptake, this is actually NOT the case.

Basically, MDMA hijacks the 5HT reuptake transport protein & transforms it into a channel to pump out from the neuron’s axon terminus even more 5HT into the synapse (thus causing the psychedelic effects). SSRI’s also bind at this same site & have a higher affinity to the receptor site — this antagonism to MDMA’s receptor site is what makes SSRI’s useful in the recovery period when coming down from MDMA’s effects allowing a reduction in neurotoxicity.”


still, if you re taking SSRIs and/or suffering from depression you shouldn’t roll. Combine MAOIs with MDMA and you will be visiting the hospital.

inna (95) (@paintedbeings) 7 years, 9 months ago ago

also came to say the same thing about antidepressants – they really don’t make you extremely happy, just able to cope or giving you a crutch while you make your way through processes of therapy to learn to walk. Also, ssris are meant to be taken in a course and not stopped abruptly – which cause problems if quality help isn’t available and the person feels out of it.
Mdma is an experience that has possible therapeutic benefits for some people/ some situations, same with psychedelics. Mdma has depressive comedown which for some impulsive and depressed folks can be bad news.
I’d put marijuana between the two on the timing – its used once in a while but not as often as mdma or psychedelics and not daily like antidepressants, and gives mildly profound experiences that can benefit some but not all.

Its really hard to determine what will work because its like selling people one idea of happiness that MUST work. One person may be thrilled over one idea that will make another person suicidal.

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